产品货号：
Z35622
中文名称：
Musk抗体
英文名称：
Anti-Musk Antibody (Clone#1429CT456.173.44)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Musk Antibody (Clone#1429CT456.173.44) |
| 指标别名 | Muscle,skeletal receptor tyrosine-protein kinase,Muscle-specific tyrosine-protein kinase receptor,MuSK,Muscle-specific kinase receptor,Musk,Nsk2 |
| 克隆性 | Monoclonal |
| 检验物种 | mouse,rat |
| 应用范围 | IHC,WB |
| 基因名称 | Musk |
| 克隆号 | 1429CT456.173.44 |
| 抗体来源 | Mouse |
| 免疫原 | This mouse Musk antibody is generated from a mouse immunized with recombinant protein from mouse Musk. |
| 计算分子量 | 97kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ),the synapse between the motor neuron and the skeletal muscle.Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK,the kinase of the complex.The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei,the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK.DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering.May positively regulate Rho family GTPases through FNTA.Mediates the phosphorylation of FNTA which promotes prenylation,recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression.Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK.May also play a role within the central nervous system by mediating cholinergic responses,synaptic plasticity and memory formation. |
| Uniprot ID | Q61006 |
相关搜索：Musk抗体，Musk单抗，Anti-Musk Antibody (Clone#1429CT456.173.44)